[caption id="attachment_1676" align="aligncenter" width="650" caption="ขอเชิญชวนนักศึกษาทุกชั้นปีเข้าฟัง Coronary circulation: physiology and mechanics"][/caption]  

Coronary circulation: physiology and mechanics Takeshi Matsumoto Bioengineering Division, Osaka University Graduate School of Engineering Science

More than 300 years ago, Scaramucci, father of coronary physiology, hypothesized that deeper coronary vessels are squeezed by the contraction of muscle fibers around them, and the vessels are refilled from the aorta during diastole. That is, the arterial inflow is greatest during diastole, whereas the venous outflow is greatest during systole. Thereafter, “Scaramucci hypothesis” has been confirmed with the progress of measurement techniques. The phase opposition of velocity waveforms between coronary arteries (diastolic predominant) and veins (systolic predominant) is the most prominent characteristic of coronary hemodynamics, making the heart unique among other organs. Mechanical stresses acting on intramyocardial blood vessels are different between inner and outer myocardial layers, and so studies of coronary hemodynamics at different transmural depth provide important information about intramyocardial influence on blood distributions in myocardium. In this lecture, following the introduction to coronary anatomy, detailed descriptions of coronary flow and vessel dynamics are given along with the measurement techniques allowing us to approach small coronary vessels. Some mechanical model concepts of coronary circulation are also provided. Then, the spatial heterogeneity of blood supply to myocardium is demonstrated. **Assoc. Prof. MATSUMOTO will also introduce his faculty, focusing on the Department of Mechanical Science and Bioengineering for the post-graduate study in Osaka.

Coronary circulation: physiology and mechanics Takeshi Matsumoto Bioengineering Division, Osaka University Graduate School of Engineering Science

More than 300 years ago, Scaramucci, father of coronary physiology, hypothesized that deeper coronary vessels are squeezed by the contraction of muscle fibers around them, and the vessels are refilled from the aorta during diastole. That is, the arterial inflow is greatest during diastole, whereas the venous outflow is greatest during systole. Thereafter, “Scaramucci hypothesis” has been confirmed with the progress of measurement techniques. The phase opposition of velocity waveforms between coronary arteries (diastolic predominant) and veins (systolic predominant) is the most prominent characteristic of coronary hemodynamics, making the heart unique among other organs. Mechanical stresses acting on intramyocardial blood vessels are different between inner and outer myocardial layers, and so studies of coronary hemodynamics at different transmural depth provide important information about intramyocardial influence on blood distributions in myocardium. In this lecture, following the introduction to coronary anatomy, detailed descriptions of coronary flow and vessel dynamics are given along with the measurement techniques allowing us to approach small coronary vessels. Some mechanical model concepts of coronary circulation are also provided. Then, the spatial heterogeneity of blood supply to myocardium is demonstrated. **Assoc. Prof. MATSUMOTO will also introduce his faculty, focusing on the Department of Mechanical Science and Bioengineering for the post-graduate study in Osaka.]]>